自己紹介

 

准教授　上井幸司　Koji Uwai

1971年5月生

博士（薬学）　東北大学

TEL : 0143-46-5775

FAX：0143-46-5701
e-mail : uwai(at)mmm.muroran-it.ac.jp


居室：教育研究４号館（H棟）H212-2室


生き方： 納得したうえでやる．やるなら楽しみながら最後までやる．終わったら飲む．

趣味：軽登山、筋トレ

好物：粉物、魚、ポテチ、酒（アルコール）


学歴

1997年3月　東北大学薬学部製薬化学科卒業

1997年3月　東北大学大学院薬学研究科博士課程前期修了

2000年3月　東北大学大学院薬学研究科博士課程後期修了（博士（薬学）取得）

  1. 学位論文題目：ドクゼリ (Cicuta virosa) の中枢毒性 C17-多価不飽和アルコールの薬学的研究


職歴

2000年4月　金沢大学薬学部教務職員

2000年9月　ドイツMax-Planck研究所 分子生理学部門博士研究員

                (2001年５月より Alexander von  Humboldt Fellow)

2002年4月　東北薬科大学助手

2006年4月　東北薬科大学講師

2011年4月　室蘭工業大学くらし環境系領域准教授

2019年4月　室蘭工業大学しくみ解明系領域准教授



受賞歴

  1. 1)第１５回生体触媒化学シンポジウム　ポスター賞（２０１１年）

  2. 2)平成２５年度日本医療薬学会　論文賞（学術論文33)

  3. 3)Outstanding Poster Award in The 5th Forum on Studies of the Environmental and Public Health Issues in the Asian Mega-cities (EPAM 2014)

  4. 4)超異分野学会北海道フォーラム2021 北海道フォーラム賞



著書

  1. 1)製剤化のサイエンス 改訂5版，第１部　製剤材料の性質，第２章　分散系，寺田勝英，高山幸三　編集，ネオメディカル，神奈川，2011，pp. 54-96

  2. 2)標準薬剤学　改訂第３版，VI　医療と薬剤学，6．医薬品の管理と供給，C　薬局製剤と病院製剤，渡辺善照，芳賀信　編集，南江堂，東京，2012，pp. 570-576


解説等

  1. 1)国立大学法人室蘭工業大学編, （分担）中野博人、上井幸司、関千草、 "新しい薬の合成　鏡像異性体を作り分ける", 室蘭工大未来をひらく技術と研究, pp.96-103, 北海道新聞社, Sapporo, Japan (2014).

  2. 2)徳樂清孝、上井幸司 “量子ドットを用いたAβ凝集阻害物質の微量ハイスループットスクリーニング法” BIO Clinica 31, 76-81 (2016). (Invited review)

  3. 3)田口 莉帆，上井 幸司，東 陽介，箕輪 貴司　”シソ科植物由来阻害物質によるアミロイドβタンパク質凝集阻害機構の円二色性スペクトルを用いた解析” ，ナノテクノロジーPick Up企画　第9回，NanotechJapan Bulletin

（http://nanonet.mext.go.jp/magazine/?plugin=pgid&id=1367）

  1. 4)上井幸司、徳樂清孝， 北海道天然資源を利用して地域・世界を救う　～アオジソの抗認知症機能性食品としての可能性～, グリーンテクノ情報，15巻， 9-13 (2019)

  2. 5)倉賀野正弘、上井幸司、徳樂清孝，蛍光イメージング技術を用いたアミロイドβ凝集阻害物質の微量ハイスループットスクリーニングシステム, 分光研究，2020年

  3. 6)上井幸司，アルツハイマー病予防を目指した，天然由来のアミロイドβ凝集阻害物質，ファルマシア，57（2），129-133，2021年

  4. 7) 山中真也、上井幸司、徳樂清孝 , 家畜衛生用消石灰に関する研究開発～研究背景と粒状化技術～LIME，603，11 ～ 15，2021年

  5. 8)中西陽菜，上井幸司，飯森俊文，農場における植物の葉の蛍光分光測定装置，分光研究，2025年




特許

  1. 1)特願2023-054595；提出日：2023年3月30日；発明者：西下  直希，徳樂  清孝，上井  幸司，渡邉  真也，倉賀野  正弘；出願人：株式会社カネカ，国立大学法人室蘭工業大学；発明の名称：オルガノイドを用いた凝集性タンパク質に対する凝集抑制活性又は凝集促進活性を評価する方法

  2. 2)特許第7446573号，登録日：2024年3月1日

  3. 特願2021-15510，提出日：2021年9月24日；発明者：大内  一敏，松村  一雄，山中  真也，徳樂  清孝，上井  幸司，中野  誠一，中野  浩幸；出願人：東洋濾紙株式会社，株式会社コア，国立大学法人室蘭工業大学；発明の名称：呈色組成物

  4. 3)特許第6820575号、登録日：2021年1月7日 

   特願2020-044879、提出日：2020年3月16日 

   発明者：中野浩幸、中野誠一、徳楽清孝、山中真也、上井幸司 

   出願人：株式会社コア、国立大学法人室蘭工業大学 

   発明の名称：可視化剤、これを用いた消毒剤の有効性判定方法及び炭酸化の検出方法 

  1. 4)PCT/JP2019/51077、提出日：2019年12月26日

   発明者：徳楽清孝、上井幸司　

   出願人：国立大学法人室蘭工業大学 

   発明の名称：アミロイド形成を評価する方法、装置及びプログラム

  1. 5)特許第7166612号，登録日：2020年8月31日

   特願2018-242280、提出日：2018年12月26日，発明者：徳楽清孝、上井幸司，出願人：国立大学法人室蘭工業大学，発明の名称：アミロイド形成を評価する方法、装置及びプログラム

  1. 6)特許6815003号，登録日：2020年12月24日

  2. 特願2016-176927; 提出日：2016年9月9日；発明者：阿部萬千雄、徳樂清孝、山中真也、上井幸司、中野博人；出願人：株式会社コア、国立大学法人室蘭工業大学；発明の名称：消毒剤

  3. 7)PCT/JPN2016/57141; 提出日：2016年3月8日；発明者：阿部萬千雄、徳樂清孝、山中真也、上井幸司、中野博人；出願人：株式会社阿部産業、国立大学法人室蘭工業大学；発明の名称：消毒剤

  4. 8)特許第6707251号、登録日：2020年6月10日

   特願2015-249378; 提出日：2015年12月22日；発明者：徳樂清孝、上井幸司；出願人：国立大学法人室蘭工業大学；発明の名称：アミロイドβタンパク質の凝集阻害組成物

  1. 9)特許第6633831号、登録日：2019年12月20日

   特願2015-047017; 提出日：2015年3月10日；発明者：阿部萬千雄、徳樂清孝、山中真也、上井幸司、中野博人；出願人：株式会社阿部産業、国立大学法人室蘭工業大学；発明の名称：消毒剤



学術論文

  1. 75) On-Site Evaluation of Constituent Content and Functionality of Perilla frutescens var. crispa Using Fluorescence Spectra

  2. Hidemichi Sano, Satoru Kawaguchi, Toshifumi Iimori , Masahiro Kuragano , Kiyotaka Tokuraku and Koji Uwai

  3. Molecules 2023, 28, 7199. https://doi.org/10.3390/

74) New boro amino amide organocatalysts for asymmetric cross aldol reaction of ketones with carbonyl compounds

  1. Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano,

  2. RSC Advances, 2023, 13(2), 888-894.

  3. 73) Thiourea fused g-amino alcohol organocatalysts for asymmetric Mannich reaction of b-keto active methylene compounds with imines

  4. Miku Nomura, Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano

  5. RSC Advances, 2023, 13(6), 3715-3722.

  6. 72)Cultivation Factors That Affect Amyloid-β Aggregation Inhibitory Activity in Perilla frutescens var. crispa

  7. Keiya Shimamori, Tomohiko Nambu, Daiki Kawamata, Masahiro Kuragano, Naoki Nishishita, Toshifumi Iimori, Shinya Yamanaka, Koji Uwai, Kiyotaka Tokuraku

  8. Foods 12, 486 (2023).

  9. 71) Microwave-assisted synthesis and formation mechanism of fluorescent carbon dots from starch

  10.       Hisahiko Shibata, Mina Abe, Kazuya Sato, Koji Uwai, Kiyotaka Tokuraku, Toshifumi Iimori

  11.       Carbohydrate Polymer Technologies and Applications, 3, Article number 100218 (2022).

  12. 70) Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii

  13.       Kenji Kubo, Hikaru Watanabe, Hiroyuki Kumeta, Tomoyasu Aizawa, Chigusa Seki, Hiroto Nakano, Kiyotaka Tokuraku, 

  14.       Koji Uwai

  15.       Bioorg. Med. Chem., 68, 116840 (2022).

  16. 69) New small gamma-turn type N-primary amino terminal tripeptide organocatalyst for solvent-free  

  17.      asymmetric aldol reaction of various ketones with aldehydes

  18.      R. Thiyagarajan, Z. Begum, C. Seki, Y. Okuyama, E. Kwon, K. Uwai, M. Tokiwa, S. Tokiwa, M. Takeshita, H. Nakan

  19.      RSC Advances，11(61)， 38925 - 38932 (2021).

  20. 68) Simple amino silyl ether organocatalyst for asymmetric hetero Diels–Alder reaction of isatins with enones

  21.    Parasuraman, D. Ganesan, Z. Begum, C. Seki, Y. Okuyama, E. Kwon, K. Uwai, M. Tokiwa, S. Tokiwa, M. Takeshita, Nakano，

  22.    CHIRALITY，33 (8)，454- 464 (2021).

67) Farm use of calcium hydroxide as an effective barrier against pathogens

       Shinji Matsuzaki, Kento Azuma, Xuguang Lin, Masahiro Kuragano, Koji Uwai, Shinya Yamanaka, Kiyotaka Tokuraku

       Scientific Reports, 11, Article number 7941 (2021).

  1. 66) Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes

      Zubeda Begum, Haruka Sannabe, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru      

      Tokiwa, Mitsuhiro Takeshita and  Hiroto Nakano,

      RSC Advances. 1, 203-209 (2021).

  1. 65) Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones

　 Perumalsamy Parasuraman, Zubeda Begum, Madhu Chennapuram, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji

　 Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano,

　 RSC Advances. 10, 17486-17491 (2020).

  1. 64)Daurichromenic Acid from the Chinese Traditional Medicinal Plant Rhododendron dauricum Inhibits Sphingomyelin Synthase and Aβ Aggregation

      Hadya Virupaksha Deepak, Mahadeva M. Swamy, Yuta Murai, Yoshiko Suga, Masaki Anetai, Takuro Yo, Masahiro

      Kuragano, Koji Uwai, Kiyotaka Tokuraku, Kenji Monde

      Molecules  25, 4077 (2020).

  1. 63)Evaluation of amyloid β42 aggregation inhibitory activity of commercial dressings by a microliter-scale high-throughput screening system using quantum-dot nanoprobes

      Masahiro Kuragano, Wataru Yoshinari, Xuguang Lin, Keiya Shimamori, Koji Uwai and Kiyotaka Tokuraku

       Foods 9, 825 (2020). 

  1. 62)Design of calcium hydroxide–based granules for livestock sanitation

      Shinya Yamanaka, Shuya Hirano, Koji Uwai, Kiyotaka Tokuraku

　  Case Studies in Chemical and Environmental Engineering 2, 100005 (2020). 

  1. 61)Sugar Based γ-Amino Alcohol Organocatalyst for Asymmetric Michael Addition of β-Keto Esters with Nitroolefins
    D. Ganesan, M. Chennapuram, Z. Begum, C. Seki, Y. Okuyama, E. Kwon, K. Uwai, M. Tokiwa, S. Tokiwa, M.Takeshita, and H. Nakano

       Heterocycles，98 (11), 1536 ～ 1545 (2019)

  1. 60)2-Azanorbornane-Based Amino Alcohol Organocatalysts for Asymmetric Michael Reaction of β-Keto Esters with Nitroolefins
    R. Togashi, M. Chennapuram, C. Seki, Y. Okuyama, E. Kwon, K. Uwai, M. Tokiwa, M. Takeshita, H. Nakano

      Eur J. Org. Chem，2019 (24)，3882 ～ 3889 (2019)

  1. 59)An automated microliter-scale high-throughput screening system (MSHTS) for real-time monitoring of protein aggregation using quantum-dot nanoprobes

      Sasaki, R., Tainaka, R., Ando, Y., Hashi, Y., Virupaksha D.H., Suga, Y., Murai, Y, Anetai, M., Monde, K., Ota, K., Ito, I.,  

      Kikuchi, H., Oshima, Y., Endo, Y., Nakao, H., Sakono, M., Uwai, K., and Tokuraku, K.

       Scientific Reports 9, Article number 2587 (2019).

  1. 57)Amino Amide Organocatalysts for Asymmetric Michael Addition of β-Keto Esters with β-Nitroolefins

       Isiaka A. Owolabi, Madhu Chennapuram, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa,

      Mitsuhiro Takeshita, Hiroto Nakano

      Bulletin of the Chemical Society, Japan,  92, 696-701 (2019).

  1. 56)Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction

      Yuta Tsukamoto, Sotaro Ikeda, Koji Uwai, Riho Taguchi, Kazuaki Chayama, Takemasa Sakaguchi, Ryo Narita, Wan-Ling

      Yao, Fumihiko Takeuchi, Yukie Otakaki, Koichi Watashi, Takaji Wakita, Hiroki Kato, Takashi Fujita

      PLOS ONE，13 (5), e0197664 (2018).

  1. 55)New Hybrid-type Squaramide-Fused Amino Alcohol Organocatalyst for Enantioselective Domino Michael Addition/Cyclization Reaction of Oxoindolines with Cyclic 1,3-DiketonesMadhu Chennapuram,

       Isiaka Alade Owolabi, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, and 

      Hiroto Nakano

     ACS OMEGA，3 (9)， 11718-11726 (2018).

  1. 54)A new type of amino amide organocatalyzed enantioselective crossed aldol reaction of ketones with aromatic aldehydes Isiaka A. Owolabi, U.V.Subba Reddy, Madhu Chennapuram, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano

     Tetrahedron，74 (36), 4705-4711 (2018).

  1. 53)Structure–activity relations of rosmarinic acid derivatives for the amyloid β aggregation inhibition and antioxidant properties

  2. R. Taguchi, K. Hatayama, T. Takahashi, T. Hayashi, Y. Sato, D. Sato, K. Ohta, H. Nakano, C. Seki, Y. Endo, K. Tokuraku, K. Uwai

  3. Eur. J. Med. Chem., 138,  1066-1075 (2017).

  4. 52) Hybrid-Type Squaramide-Fused Amino Alcohol Organocatalysts for Enantioselective Diels–Alder Reactions of 3-Hydroxy-2-Pyridones with Maleimides

  5. Madhu Chennapuram, U. V. Subba Reddy, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano

  6. European Journal of Organic Chemistry, 2017, 4633-4641 (2017).

  7. 51)A Diamino Alcohol Catalyzed Enantioselective Crossed Aldol Reaction of Acetaldehyde with Isatins – A Concise Total Synthesis of Antitumor Agents

  8. U. V. Subba Reddy, Madhu Chennapuram, Kento Seki, Chigusa Seki, Bheemreddy Anusha, Eunsang Kwon, Yuko Okuyama,  Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano

  9. European Journal of Organic Chemistry, 2017, 3847-3885 (2017).

  10. 50)Hybrid-Type Squaramide-Fused Amino Alcohol Organocatalysts for Enantioselective Nitro-Aldol Reaction of Nitromethane with Isatins

  11. Madhu Chennapuram, U. V. Subba Reddy, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano

  12. European Journal of Organic Chemistry, 2017, 1638-1646 (2017).

  13. 49)T. Takahashi, U.V. S. Reddy, Y. Kohari, C. Seki, T. Furuyama, N. Kobayashi, Y. Okuyama, E. Kwon, K. Uwai, M. Tokiwa, M. Takeshita, H. Nakano

  14. Simple primary β-amino alcohol catalyzed enantioselective Diels-Alder reaction of 3-hydroxy-2-pyridones

  15. Tetrahedron Letters, 57 (51), 5771-5776 (2016)

  16. 48) A. Ogasawara, U.V. S. Reddy, C. Seki, Y. Okuyama, K. Uwai, M. Tokiwa, M. Takeshita, H. Nakano

  17. 2-Azanorbornane-based amine organocatalyst for enantioselective aldol reaction of isatins with ketones

  18. Tetrahedron: Asymmetry, 27(20-21), 1062-1068 (2016)

  19. 47)J. Kimura, U. V. S. Reddy, Y. Kohari, C. Seki, Y. Mawatari, K. Uwai, Y. Okuyama, E. Kwon, M. Tokiwa, M. Takeshita, T. Iwasa and H. Nakano

  20. Simple Primary Amino Amide Organocatalyst for Enantioselective Aldol Reactions of Isatins with Ketones 

  21. Eur. J. Org. Chem., 2016, 3748-3756 (2016)

  22. 46)M Galaqin, K Uwai, M Yuguchi, T Iwasa

  23. Simultaneous analysis of major ingredients of Gardenia fruit by HPLC-MS/TQMS method

  24. Mongolian J. Chem.17, 34-37(2016)

45) K. Sano, Y. Kohari, H. Nakano, C. Seki, M. Takeshita, M. Tokiwa, Y. Hirose, K. Uwai

  1. Lipase-Catalyzed Domino Michael-Aldol Reaction of 2-Methyl-1,3-Cycloalkanedione and Methyl Vinyl Ketone for the Synthesis of Bicyclic Compounds

  2. Synthetic Communications, 46 (1), 46-54 (2016). 

  3. 44)J. Kumagai, T. Otsuki, U. V. Subba Reddy, Y. Kohari, C. Seki, K. Uwai, Y. Okuyama,  E. Kwon, M. Tokiwa, M. Takeshita,

  4. H. Nakano

  5. Chiral primary amino alcohol organobase catalysts for the asymmetric Diels-Alder reactions of anthrones with maleimides

  6. Tetrahedron: Asymmetry, 26 (24), 1423-1439 (2015).

  7. 43)T. Otsuki, J. Kumagai, Y. Kohari, Y. Okuyama, E. Kwon, C. Seki, K. Uwai, Y. Mawatari, N. Kobayashi, T.o Iwasa, M.

  8. Tokiwa, M. Takeshita, A. Maeda, A. Hashimoto, K. Turuga, H. Nakano

  9. Silyloxy Amino Alcohol Organocatalyst for Enantioselective 1,3-Dipolar Cycloaddition of Nitrones to α,β- Unsaturated Aldehydes

  10. Eur. J. Org. Chem., 2015 (33), 7292-7300 (2015).

42) J. Kumagai, Y. Kohari, C. Seki, K. Uwai, Y. Okuyama, E. Kwon, H. Nakano

  1. Chiral Primary Amino Amide Alcohol Organocatalyst for the Asymmetric Michael Addition of 4-Hydroxycoumarin with α,β-Unsaturated Ketones

  2. Heterocycles, 90 (2), 1124-1134 (2015).

41) T. Ogara; T. Takahashi, H. Yasui,  K. Uwai, K. Tokuraku

  1. Evaluation of the effects of amyloid- beta aggregation from seaweed extracts by a microliter-scale high-throughput screening system with a quantum dot nanoprobe

  2. J. Biosci. Bioeng.,120 (1), 45-50 (2015).

  3. 40)Y. Kohari, Y. Okuyama, E. Kwon, T. Furuyama, N. Kobayashi, T. Otuki, J. Kumagai, C. Seki, K. Uwai, G. Dai, T. Iwasa, H. Nakano

  4. Enantioselective Diels-Alder Reaction of 1,2-Dihydropyridines with Aldehydes using beta-Amino Alcohol Organocatalyst

  5. J. Org. Chem., 79 (20), 9500-9511 (2014).

  6. 39) K. Uwai, Y. Okuyama,  H. Nakano,, K. Furukawa, E. Hiroshima, H. Azuma, M. Watanabe, T. Matsumoto,  M. Tokiwa, M. Takeshita,

  7. Biotransformation of organic compounds in vivo using larvae of beetles (Allomyrina dichotoma) as biocatalysts

  8. Biocat. Agric. Biotech. 3 (4), 129-133 (2014).

  9. 38) J. Kumagai, Y. Kohari, C. Seki, K. Uwai, Y. Okuyama, E. Kwon, H. Nakano

  10. Chiral Primary Amino Amide Alcohol Organocatalyst for the Asymmetric Michael Addition of 4-Hydroxycoumarin with α,β-Unsaturated Ketones

  11. Heterocycles, 90 (2), 1124-1134 (2014).

  12. 37)Y. Ishigaki, H. Tanaka, H. Akama, T. Ogara, K. Uwai, K. Tokuraku

  13. A Microliter-scale High-throughput Screening System with Quantum-dot Nanoprobes for Amyloid-β aggregation Inhibitors

  14. PLoS ONE 8(8): e72992. doi:10.1371/journal.pone.0072992

  15. 36) K. Sano, S. Saito, Y. Kohari, H. Nakano, Y. Hirose, M. Tokiwa, M. Takeshita, K. Uwai

  16. Development of a Novel Method for Warfarin Synthesis via Lipase-Catalyzed Stereoselective Michael Reaction

  17. Heterocycles, 87 (6), 1269-1278 (2013)

  18. 35)N. D. M. R. Hutabarat, C. Seki, T. Shimizu, M. Hirama, Y. Kohari, H. Nakano, K. Uwai, N. Takano, E. Kwon, H. Matsuyama

  19. Highly Enantioselective Synthesis of Isoquinuclidine by Diels-Alder Reaction of 1,2-Dihydropyridine Utilizing Chiral Bisoxazoline-Cu(II) Complex

  20. Heterocycles, 86 (1), 203-217 (2012)

  21. 34)Y. Sakuta, Y. Kohari, N. D. M. R. Hutabarat, K. Uwai, E. Kwon, Y. Okuyama, C. Seki, H. Matsuyama, N. Takano, M. Tokiwa, M. Takeshita, H. Nakano

  22. Chiral primary Amino Silyl Ether Organocatalyst for the Enantioselective Diels-Alder Reaction of 1,2-Dihydropyridines with Aldehydes

  23. Heterocycles, 86 (2), 1379-1389 (2012)

  24. 33)T. Hayashi, K. Uwai, E. Sasaki, K. Sasaki, Y. Iwabuchi, H. Agatsuma, T. Suzuki

Compatibility of heparin sodium in intravenous line with nicardipine injected from a side tube via T-shape stopcock

Jpn. J. Pharm. Health Care Sci., 38 (11), 679-387 (2012)：平成２５年度日本医療薬学会　論文賞受賞

  1. 32)C. Seki, M. Hirama, T. Sato, S. Takeda, Y. Kohari, K. Ishigaki, M. Ohuchi, K. Yokoi, H. Nakano, K. Uwai, N. Takano, K. Umemura, H. Matsuyama

One Step Synthesis of Optically Active Diazabicyclo[3.3.0]octanones or Diazabicyclo[4.3.0]nonanones by Asymmetric Conjugate Addition of Cyclic Hydrazine

Heterocycles, 85 (5), 1045-1052 (2012)

  1. 31)C. Seki, M. Hirama, N.D.M. R. Hutabarat, J. Takada, C. Suttibut, H. Takahashi, T. Takaguchi, Y. Kohari, H. Nakano, K. Uwai, N. Takano, M. Yasui, Y. Okuyama, M. Takeshita, H. Matsuyama

Asymmetric synthesis of isoquinuclidines by DielseAlder reaction of 1,2-dihydropyridine utilizing a chiral Lewis acid catalyst

Tetrahedron, 68 (6), 1774-1781 (2012)

  1. 30)M. Hirama, C. Suttibut, N. D. M. R. Hutabarat, C. Seki, N. Sakuta, T. Tsuchiya, Y. Kohari, H. Nakano, K. Uwai, N. Takano, M. Yasui, Y. Okuyama, K. Osone, M. Takeshita, H. Matsuyama

Asymmetric Synthesis of Isoquinuclidine by Diels-Alder Reaction of 1,2-Dihydropyridine and Chiral Dienophile Utilizing a Chiral Lewis Acid

Heterocycles, 84 (1), 377-384 (2012)

  1. 29)C. Suttibut, Y. Kohari, K. Igarashi, H. Nakano, M. Hirama, C. Seki, H. Matsuyama, K. Uwai, N. Takano, Y Okuyama, K. Osone, M. Takeshita, E. Kwon

A highly enantioselective Diels–Alder reaction of 1,2-dihydropyridine using a simple β-amino alcohol organocatalyst for a practical synthetic methodology of oseltamivir intermediate

Tetrahedron Lett., 52 (37), 4745-4748 (2011)

  1. 28) 吉川真一，鈴木美，村田亮，吉田進，上井幸司，鈴木常義、竹下光弘

ロキソプロフェンナトリウム錠後発医薬品の単回投与での臨床効果

ペインクリニック，31(5), 635-640(2010).

  1. 27) S. Yoshikawa, R. Murata, S. Shida, K. Uwai, T. Suzuki, S. Katsumata, M. Takeshita

Evaluation of correlation between dissolution rates of loxoprofen tablets and their surface morphology observed by scanning electron microscope and atomic force microscope.

Chem. Pharm. Bull., 58(1), 34-37 (2010).

  1. 26)S. Masuda, R. Oka, K. Uwai, Y. Matsuda, T. Shiraishi, Y. Nakagawa, T. Shoji, C. Mihara, M. Takeshita, K. Ozawa

Development of clinical application for a nutritional prescription support system for total parenteral/enteral nutrition.

Yakugaku Zasshi, 129 (9), 1077-1086 (2009).

  1. 25) Y. Nishiuchi, H. Nakano, Y. Araki, R Sato, R. Fujita, K. Uwai, M. Takeshita

Reactivity and efficient recycling of a chiral Pd-BINAP catalyst for catalytic asymmetric Diels-Alder reaction in ionic liquid.

Heterocycles, 77(2), 1323-1331 (2009).

  1. 24)Y. Okuyama, H. Nakano, Y. Watanabe, M. Makabe, M. Takeshita, K. Uwai, C. Kabuto, E. Kwon

Organocatalitic activity of 4-hydroxy-prolinamide alchol with different noncovalent coordination sites in asymmetric Michael and direct aldol reactions.

Tetrahedron Lett., 50, 193-197 (2009).

  1. 23)H. Nakano, Y. Nishiuchi, K. Takahashi, R. Fujita, K. Uwai, M. Takeshita  

Chiral cationic Pd-phosphinooxazolidine catalysts for a highly efficient asymmetric diels-alder reaction in ionic liquids.  

Heterocycles, 76(1), 381-390 (2008). 

  1. 22) Y. Osanai, S. Kanno, K. Uwai, M. Takeshita, M. Ishikawa

Inhibitory effect of octylcaffeate on lipopolysaccharaide-induced nitric oxide production in macrophages.

Pharmacometrics, 75 (1/2), 19-24 (2008).

  1. 21) K. Uwai, Y. Osanai, T. Imaizumi, S. Kanno, M. Takeshita, M. Ishikawa

Inhibitory effect of the alkyl side chain of caffeic acid analogues on lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages.

Bioorg. Med, Chem., 16, 7795-7803 (2008).

  1. 20)S. Kanno, T. Ohtake, Y. Osanai, K. Kurauchi, M. Ujibe, K. Uwai, M. Takeshita, S. Satoh, M. Ishikawa 

Trimidox-induced apoptosis is mediated through induction of p53 in NALM-6 cells.   

J. Pharmacol. Sci., 106(3), 521-524 (2008).

  1. 19)K. Uwai, N. Konno, Y. Yasuta, M. Takeshita

Electronic effects of para-substituon on acetophenones in the reaction of rat liver 3α-hydroxysteroid dehydrogenase.

Bioorg. Med. Chem., 16, 1084-1089 (2008).

  1. 18)R. Oka，K. Uwai, T. Toyoguchi, T.i Shiraishi, Y. Nakagawa, M. Takeshita

Stability of magnesium oxide products kept in single-dose packages.

Jpn. J. Pharm. Health Care Sci., 33 (12), 1013-1019 (2007).

  1. 17)S. Kanno, K. Kakuta, Y. Kitajima, Y. Osanai, K. Kurauchi, T. Ohtake, M. Ujibe, K. Uwai, M. Takeshita, M. Ishikawa  

Inhibitory effect of trimidox on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages.   

J. Pharmacol. Sci., 104(3), 278-281 (2007).

  1. 16)S. Kanno, M. Kakuta, Y. Kitajima,Y. Osanai, K. Kurauchi, T. Ohtake, M. Ujibe, K. Uwai, M. Takeshita, M.  Ishikawa

Preventive effect of trimidox on oxidative stress in U937 cell line.

Biol. Pharm. Bull., 30(5), 994-998 (2007).

  1. 15) S. Kanno, K. Uwai, A. Tomizawa, T. Hiura, Y. Osanai, M. Ujibe, M. Takeshita, T. Ohtake, K. Kimura, M. Ishikawa

Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukemia cells.

Basic and Clinical Pharmacology and Toxicology, 98 (1), 44-50 (2006).

  1. 14) M. Ujibe, S. Kanno, Y. Osanai, K. Koiwai, T. Ohtake, K. Kimura, K. Uwai, M. Takeshita, M. Ishikawa

Octylcaffeate induced apoptosis in human leukemia U937 cells.

Biol. Pharm. Bull., 28 (12), 2338-2341 (2005).

  1. 13)K. Uwai, N. Konno, S. Kitamura, S. Ohta, M. Takeshita

Purification and characterization of rat liver enzyme catalyzing stereoselective reduction of acetylpyridines.

  1. Chirality, 17 (8), 494-500 (2005).

  2. 12)K. Uwai, M. Tani, Y. Ohtake, S. Abe, A. Maruko, T. Chiba, Y. Hamaya, Y. Ohkubo, M. Takeshita

Photodegradation products of propranolol: the structures and pharmacological studies.

Life Sci, 78, 357-365 (2005).

  1. 11)M. Takeshita, T. Chiba, K. Uwai, K. Hisamichi, N. Sasaki, Y. Hamaya

Photostability of naftopidil.

Jpn. J. Pharm. Health Care Sci., 31. 464-469 (2005).

  1. 10)K. Uwai, H. Uchiyama, S. Sakurada, C. Kabuto, M. Takeshita

Syntheses and receptor-binding study of derivatives of the opioid antagonist naltrexone.

Bioorg. Med. Chem., 12, 417-421 (2004).

  1. 9)M. Völkert, K. Uwai, A. Tebbe, B. Popkirova, M. Wagner, J. Kuhlmann, H. Waldmann

Synthesis and biological activity of photoactivatable N-Ras-peptides and proteins.

J. Am. Chem. Soc., 125, 12749-12758 (2003).

  1. 8)K. Uwai, H. Sato, N. Kazakami, H. Matsuzaki, M. Takeshita

Synthesis and reduction of (S)-(-)-nicotine-N’-oxide and N,N’-dioxides by rat liver S-9 fraction.

Arkivoc, 8, 211-219 (2003).

  1. 7) J. Kuhlmann, A. Tebbe, M. Völkert, M. Wagner, K. Uwai, H. Waldmann

Photoactivatable synthetic Ras proteins: "baits" for the identification of plasma-membrane-bound binding partners of Ras.

Angew. Chem. Int. Ed., 41(14), 2546-2550 (2002).

  1. 6)K. Uwai, K. Ohashi, Y. Takaya, Y. Oshima, K. Furukawa, K.,Yamagata, T. Ohmura, S. Okuyama

Virol A, a toxic polyacetylenic alcohol of Cicuta virosa, inhibits the GABA-induced Cl-current in the rat hippocampal CA1 Neurons.

Brain Research, 889, 174-180 (2001).

  1. 5)K. Uwai, K. Ohashi, Y. Takaya, T. Ohta, T. Tadano, K. Kisara, K. Shibusawa, R. Sakakibara, Y. Oshima

Exploring the structural basis of neurotoxicity in C17-polyacetylenes isolated from water hemlock.

J. Med. Chem., 43, 4508-4515 (2000).

  1. 4) K. Uwai, Y. Oshima, T. Sugihara, T. Ohta

Syntheses and stereochemical assignment of toxic C17-polyacetylenic alcohols, virols A, B, and C, isolated from water hemlock (Cicuta virosa).

Tetrahedron, 55, 9469-9480 (1999).

  1. 3)T. Ohta, K. Uwai, R. Kikuchi, S. Nozoe, Y. Oshima, K. Sasaki, F. Yoshizaki 

Absolute stereochemistry of cicutoxin and related toxic polyacetylenic alcohols from Cicuta virosa.

Tetrahedron, 55, 12087-12098 (1999).

  1. 2) Y. Takaya, H. Tasaka, T. Chiba, K. Uwai, M. Tanitsu, H.-S. Kim, Y. Wataya, M. Miura, M. Takeshita, Y. Oshima

New type of feburifugine analogues, bearing a quinolizine moiety, show potent antimalarial activity against Plasmodium malaria parasite.

J. Med. Chem., 42, 3163-3166(1999).

  1. 1)K. Hiroya, K. Uwai, K. Ogasawara

Enantio- and diastereocontrolled synthesis of epibatidine analogues.

Chem. Pharm. Bull., 43, 901-903 (1995).